1 00:00:00,000 --> 00:00:00,000 2 00:00:04,340 --> 00:00:07,780 Dr Saadawi , You may go ahead . Thank 3 00:00:07,780 --> 00:00:10,640 you . Yeah . Is that 4 00:00:11,840 --> 00:00:13,390 mm ? Have a 5 00:00:17,740 --> 00:00:19,060 and 6 00:00:22,540 --> 00:00:23,540 Yeah , 7 00:00:28,240 --> 00:00:28,570 that 8 00:00:33,240 --> 00:00:36,560 the that . That that . That That That . 9 00:00:36,560 --> 00:00:38,060 That . That That . 10 00:00:43,640 --> 00:00:47,450 That Yeah , that 11 00:00:48,240 --> 00:00:51,150 That . That . Yeah . Yeah , 12 00:00:51,540 --> 00:00:53,470 e yeah . 13 00:00:55,440 --> 00:00:59,130 To a number of important questions that 14 00:00:59,140 --> 00:01:02,040 would effectively relate to important 15 00:01:02,140 --> 00:01:04,910 progression or development . Such as , 16 00:01:04,910 --> 00:01:08,320 for instance , can we use , at least in 17 00:01:08,320 --> 00:01:10,350 some of the populations , immunize 18 00:01:10,740 --> 00:01:13,360 somewhat lower dude into those 19 00:01:13,360 --> 00:01:16,490 regiments , Which may be an alternative 20 00:01:16,500 --> 00:01:18,970 that is much more powerful to induce a 21 00:01:18,970 --> 00:01:21,192 high immune response than the one those 22 00:01:21,192 --> 00:01:23,192 vaccine , for instance , Where , of 23 00:01:23,192 --> 00:01:25,526 course , also , as we already announced , 24 00:01:25,526 --> 00:01:28,560 started the first adolescent Clinical 25 00:01:28,560 --> 00:01:31,890 trial from the age of 12 26 00:01:31,890 --> 00:01:35,660 to 18 on finally also 27 00:01:35,740 --> 00:01:39,550 have started the practical aspect 28 00:01:39,550 --> 00:01:43,360 Operational aspects off gearing towards 29 00:01:43,360 --> 00:01:45,193 identification of quality neural 30 00:01:45,193 --> 00:01:48,210 protection . Uh , in your current of 31 00:01:48,210 --> 00:01:50,377 protection story , which would be very 32 00:01:50,377 --> 00:01:53,550 important . Thio identify Thio 33 00:01:54,040 --> 00:01:56,440 help bridge this vaccine as well as 34 00:01:56,440 --> 00:01:59,090 other vaccines . Now that potentially 35 00:01:59,100 --> 00:02:01,211 running off placebo controlled ethics 36 00:02:01,211 --> 00:02:02,878 Israel's and they become more 37 00:02:02,878 --> 00:02:04,933 challenging , particularly in the US 38 00:02:04,933 --> 00:02:07,044 and in countries where vaccines would 39 00:02:07,044 --> 00:02:10,890 be approved . And in news the J and J . 40 00:02:10,890 --> 00:02:12,946 Johnson Vaccine program continues to 41 00:02:12,946 --> 00:02:14,946 progress Very well . We told you on 42 00:02:14,946 --> 00:02:17,112 Monday that the trial we couldn't have 43 00:02:17,112 --> 00:02:19,168 closed . We are now working with the 44 00:02:19,168 --> 00:02:22,040 company diligently to optimize data 45 00:02:22,040 --> 00:02:24,550 cleaning events on 46 00:02:24,560 --> 00:02:28,460 assessment . Andi 47 00:02:28,460 --> 00:02:32,130 also CMC aspect with the hope that we 48 00:02:32,130 --> 00:02:35,750 would be able to file for the U A 49 00:02:35,900 --> 00:02:39,100 late in January or more likely early in 50 00:02:39,100 --> 00:02:41,170 February and have vaccine those is 51 00:02:41,300 --> 00:02:44,200 available and approved for using U . S 52 00:02:44,200 --> 00:02:47,660 population as of the month of February . 53 00:02:48,140 --> 00:02:50,640 The AstraZeneca Phase three program in 54 00:02:50,640 --> 00:02:52,696 the U . S . Is also progressing very 55 00:02:52,696 --> 00:02:55,770 well . More than 70 27,000 subjects 56 00:02:55,770 --> 00:02:58,070 recruited in this 30,000 subject trial , 57 00:02:58,070 --> 00:03:00,730 so we can see that the closure of the 58 00:03:00,740 --> 00:03:03,270 trial in terms of recruitment eyes 59 00:03:03,270 --> 00:03:06,420 going to be soon and clearly this 60 00:03:06,420 --> 00:03:08,760 program will also be potentially 61 00:03:08,760 --> 00:03:11,750 impacted by further analysis of the 62 00:03:11,750 --> 00:03:15,500 ongoing UK on Brazil trials . 63 00:03:15,510 --> 00:03:17,732 When that happens , of course , we will 64 00:03:17,732 --> 00:03:20,860 allow learn about that . Together , the 65 00:03:20,860 --> 00:03:23,640 two protein vaccine programs continue 66 00:03:23,640 --> 00:03:25,840 to progress . Novavax is in advanced 67 00:03:25,840 --> 00:03:27,951 discussions with the FDA were gearing 68 00:03:27,951 --> 00:03:30,650 up to start the face retrial anytime on 69 00:03:30,650 --> 00:03:32,428 the Senaki program . As for the 70 00:03:32,428 --> 00:03:34,530 announcement is , we are designing 71 00:03:34,530 --> 00:03:36,710 together with the company the face to 72 00:03:36,720 --> 00:03:40,690 be plans that can enable further 73 00:03:40,690 --> 00:03:42,710 development off this vaccine in 74 00:03:42,710 --> 00:03:44,932 particular , for instance , potentially 75 00:03:44,932 --> 00:03:47,266 the use of Indian College of Protection . 76 00:03:47,266 --> 00:03:49,266 If those are identified through the 77 00:03:49,266 --> 00:03:51,800 modern and and potentially the Pfizer 78 00:03:51,800 --> 00:03:54,440 vaccine program , these are the news 79 00:03:54,450 --> 00:03:56,550 directly on the vaccine portfolio . 80 00:03:56,940 --> 00:04:00,680 Clearly , you are also aware off the UK 81 00:04:00,680 --> 00:04:02,624 variants and now the South African 82 00:04:02,624 --> 00:04:05,790 variants on their potential presence in 83 00:04:05,790 --> 00:04:08,790 the U . S . I think while there is data 84 00:04:08,790 --> 00:04:11,690 suggesting that not demonstrating that 85 00:04:11,690 --> 00:04:14,300 these variants maybe more infectious 86 00:04:14,440 --> 00:04:16,670 than the currently , 87 00:04:16,680 --> 00:04:19,660 uh on the 88 00:04:20,940 --> 00:04:23,340 most important vaccine strain sorry 89 00:04:23,350 --> 00:04:25,572 Harris strain in the population , there 90 00:04:25,572 --> 00:04:28,640 is no evidence to support that they're 91 00:04:28,640 --> 00:04:32,530 PathoGenesis or impact people said 92 00:04:32,540 --> 00:04:36,240 here any different . There are also 93 00:04:36,250 --> 00:04:38,194 discussions and all the scientific 94 00:04:38,194 --> 00:04:40,490 conversations actually around the 95 00:04:40,500 --> 00:04:42,620 setting up the potential allergic 96 00:04:42,620 --> 00:04:45,830 reactions . Associate ID with fighting 97 00:04:45,830 --> 00:04:48,052 vaccine potentially what we're thinking 98 00:04:48,052 --> 00:04:51,200 about potential physical tries to thio 99 00:04:51,210 --> 00:04:53,380 assess that on the therapeutic 100 00:04:53,380 --> 00:04:55,610 portfolio side of things . The most 101 00:04:55,610 --> 00:04:58,230 important news , of course , is the 102 00:04:58,240 --> 00:05:00,940 announcement of the veteran partnership 103 00:05:00,940 --> 00:05:03,107 with work on Caribbean . As you know , 104 00:05:03,107 --> 00:05:05,218 I don't call me in a few weeks back , 105 00:05:05,218 --> 00:05:08,350 and now we have finalized and announced 106 00:05:08,360 --> 00:05:10,304 a new agreement to acquire between 107 00:05:10,304 --> 00:05:14,110 260,000 closes off the city 108 00:05:14,110 --> 00:05:17,610 24 FC program Medicine the phone 109 00:05:17,610 --> 00:05:19,721 commune has developed . Reminded that 110 00:05:19,721 --> 00:05:23,690 this , uh , medicine has shown 111 00:05:23,700 --> 00:05:27,060 impressive efficacy in an internal 112 00:05:27,070 --> 00:05:30,830 assed part of a first , 113 00:05:30,840 --> 00:05:34,420 uh , interview analysis of their face 114 00:05:34,420 --> 00:05:36,642 free program . E want to stop there and 115 00:05:36,642 --> 00:05:38,970 pass on to my partner and co leader ? 116 00:05:39,110 --> 00:05:42,380 General problem , Dr . Slowly . Thanks . 117 00:05:42,380 --> 00:05:44,491 Great . Run down is always and , uh , 118 00:05:44,491 --> 00:05:46,810 just good afternoon , everybody , as we 119 00:05:46,820 --> 00:05:49,230 get settled in , uh , right before the 120 00:05:49,230 --> 00:05:51,230 holidays , who's been a big week of 121 00:05:51,230 --> 00:05:54,250 delivery of vaccines ? Uh , over 122 00:05:54,260 --> 00:05:58,210 7800 deliveries by 123 00:05:58,210 --> 00:06:01,630 the end of tomorrow . Aziz , we are 124 00:06:01,630 --> 00:06:05,060 delivering the 7.9 million doses of 125 00:06:05,060 --> 00:06:07,140 vaccine that were allocated for this 126 00:06:07,140 --> 00:06:09,290 week around the country . Really a 127 00:06:09,290 --> 00:06:11,950 tremendous feat . Yesterday morning , 128 00:06:11,950 --> 00:06:14,930 we allocated for next week's ordering 129 00:06:14,940 --> 00:06:18,860 4.67 million . 2.67 a 130 00:06:18,860 --> 00:06:21,490 fighter and two million of Madonna 131 00:06:21,500 --> 00:06:23,667 jurisdictions were working through the 132 00:06:23,667 --> 00:06:25,980 planning . Now the micro planning on . 133 00:06:25,980 --> 00:06:27,990 Then as early as tomorrow morning 134 00:06:28,000 --> 00:06:30,000 throughout the day , they can begin 135 00:06:30,000 --> 00:06:32,000 ordering for deliveries . That will 136 00:06:32,000 --> 00:06:35,040 happen next week . So today we've 137 00:06:35,040 --> 00:06:38,590 allocated 15.5 million doses of vaccine 138 00:06:38,600 --> 00:06:41,990 on we are on track to allocate 139 00:06:42,000 --> 00:06:45,640 another 4.5 to 5 million next week , 140 00:06:45,650 --> 00:06:48,260 which will bring us to 20 million doses 141 00:06:48,270 --> 00:06:51,770 of vaccine allocated to America before 142 00:06:51,770 --> 00:06:54,210 the end of the year . Wolf finish those 143 00:06:54,210 --> 00:06:57,420 deliveries in the first week of January . 144 00:06:57,430 --> 00:07:01,370 Uh , 456 January To 145 00:07:01,370 --> 00:07:03,590 make sure that all those doses are 146 00:07:03,590 --> 00:07:05,534 available to the American people , 147 00:07:08,340 --> 00:07:10,980 we are learning some lessons as we go 148 00:07:10,980 --> 00:07:13,510 that I wanted to share with you , Uh , 149 00:07:13,520 --> 00:07:17,030 tremendous Herculean task work being 150 00:07:17,030 --> 00:07:20,890 done by Pfizer , Madonna , McKesson , 151 00:07:20,890 --> 00:07:23,940 ups and FedEx . Uh , we went with them 152 00:07:23,940 --> 00:07:26,660 because they are the best on they know 153 00:07:26,660 --> 00:07:29,460 how to do this , but at the volume and 154 00:07:29,460 --> 00:07:31,870 the scale of what we're doing every day , 155 00:07:31,940 --> 00:07:34,070 we are learning some things that help 156 00:07:34,070 --> 00:07:36,126 us just continue to get better every 157 00:07:36,126 --> 00:07:39,170 day . So as we figure out the pace for 158 00:07:39,170 --> 00:07:41,590 picking and packing vaccines and put 159 00:07:41,590 --> 00:07:43,812 him in in boxes , making sure we do the 160 00:07:43,812 --> 00:07:45,868 right quality control , we've had to 161 00:07:45,868 --> 00:07:48,800 adjust our timelines . Just just a 162 00:07:48,810 --> 00:07:51,180 mathematical problem to make sure we 163 00:07:51,180 --> 00:07:53,800 start on the right time and we finish 164 00:07:53,810 --> 00:07:56,280 in order to make the deliveries . We 165 00:07:56,280 --> 00:07:59,050 are working with the States in 166 00:07:59,050 --> 00:08:01,420 collaboration to make sure that we have 167 00:08:01,430 --> 00:08:04,420 a continuous contact with everybody 168 00:08:04,420 --> 00:08:06,920 who's receiving the vaccine so that we 169 00:08:06,920 --> 00:08:09,031 can make sure that they know when the 170 00:08:09,031 --> 00:08:11,142 package is arriving or if the package 171 00:08:11,142 --> 00:08:13,630 will be late . We're confirming on 172 00:08:13,640 --> 00:08:15,862 always getting better at development of 173 00:08:15,862 --> 00:08:18,560 addresses to ensure that we know the 174 00:08:18,560 --> 00:08:20,616 right places to go to and there's no 175 00:08:20,616 --> 00:08:23,180 delay there . Uh , and we continue to 176 00:08:23,180 --> 00:08:25,670 grow in our efforts with the long term 177 00:08:25,680 --> 00:08:29,320 care facilities . Aziz , we , uh , 178 00:08:29,330 --> 00:08:32,910 enter and help them administer shots in 179 00:08:32,910 --> 00:08:35,590 volume . Really a terrific effort , 180 00:08:35,590 --> 00:08:38,140 their collaboration with all the states 181 00:08:38,150 --> 00:08:41,900 on as we operationalized that 182 00:08:41,910 --> 00:08:44,440 that that task , we get better every 183 00:08:44,440 --> 00:08:47,240 day . And when I say we I mean CVS and 184 00:08:47,240 --> 00:08:50,450 Walgreens who are really doing terrific 185 00:08:50,450 --> 00:08:53,270 work . At the end of the day , we have 186 00:08:53,270 --> 00:08:57,130 had a handful of packages that we 187 00:08:57,130 --> 00:08:59,680 tried to deliver that we're not 188 00:08:59,680 --> 00:09:01,791 destined for the right place . But we 189 00:09:01,791 --> 00:09:04,970 captured them before , Um , they were 190 00:09:04,980 --> 00:09:07,230 dropped off and we rerouted them to the 191 00:09:07,230 --> 00:09:10,460 right place on . We had a couple of 192 00:09:10,460 --> 00:09:12,682 miss not miss shipments , but shipments 193 00:09:12,682 --> 00:09:15,120 that didn't go out on the right day . 194 00:09:15,130 --> 00:09:17,241 We wanted them to go out for delivery 195 00:09:17,241 --> 00:09:20,430 on Tuesday and delivery on Wednesday on 196 00:09:20,430 --> 00:09:23,000 DSO We had to work through our after 197 00:09:23,000 --> 00:09:25,210 action report and get that corrected . 198 00:09:25,220 --> 00:09:28,130 Uh , really Torrens work being done ? 199 00:09:28,140 --> 00:09:31,730 Uh , a tactical level , um Ato 200 00:09:31,730 --> 00:09:33,750 worker level toe to make sure they 201 00:09:33,750 --> 00:09:35,790 understand how to do this again . 202 00:09:35,800 --> 00:09:38,310 Reminder . Over the last two weeks , 203 00:09:38,310 --> 00:09:42,080 we've done over , uh , 10,000 204 00:09:42,090 --> 00:09:44,630 shipments to different locations and 205 00:09:44,640 --> 00:09:47,160 really pretty impressive on . So I just 206 00:09:47,160 --> 00:09:49,382 passed to you that we're learning we're 207 00:09:49,382 --> 00:09:51,438 getting better , and every day we're 208 00:09:51,438 --> 00:09:53,670 getting stronger . Our goal is is we 209 00:09:53,670 --> 00:09:55,990 come out of the holidays were in a 210 00:09:55,990 --> 00:09:58,190 steady drumbeat of continuous vaccine 211 00:09:58,190 --> 00:10:00,830 delivery . We want it to be even 212 00:10:00,830 --> 00:10:03,780 smoother every single day . So good . 213 00:10:03,790 --> 00:10:06,450 Good job so far . Continue to do better 214 00:10:06,450 --> 00:10:09,900 as we go . We're working 215 00:10:09,910 --> 00:10:12,720 now . We're talking to the jurisdiction 216 00:10:12,720 --> 00:10:15,590 slash states on the delivery of the 217 00:10:15,590 --> 00:10:19,030 second dose . Remember , we've talked 218 00:10:19,030 --> 00:10:21,141 about we're delivering the first dose 219 00:10:21,141 --> 00:10:24,410 of the two dose regiment on we've been 220 00:10:24,420 --> 00:10:28,240 holding on to the second dose . We do . 221 00:10:28,250 --> 00:10:30,139 We did that to make sure that the 222 00:10:30,139 --> 00:10:33,480 supply chain was sufficient to ensure 223 00:10:33,480 --> 00:10:35,740 the second dose was there . Well , 224 00:10:35,750 --> 00:10:37,650 Pfizer vaccine started being 225 00:10:37,650 --> 00:10:40,600 distributed last week on . It will be 226 00:10:40,600 --> 00:10:42,960 time for that vaccine to start going 227 00:10:42,960 --> 00:10:45,127 out to the American people next week . 228 00:10:45,127 --> 00:10:47,016 So we've established in elaborate 229 00:10:47,016 --> 00:10:50,330 communication strategy a TTL levels to 230 00:10:50,330 --> 00:10:52,441 make sure everybody's tracking this . 231 00:10:52,441 --> 00:10:55,650 We work through , um , different levels 232 00:10:55,660 --> 00:10:58,850 of teaching on instructions on how to 233 00:10:58,850 --> 00:11:00,683 make sure we're doing that . And 234 00:11:00,683 --> 00:11:03,320 everybody is informed . We know how to 235 00:11:03,320 --> 00:11:05,760 do this . American knows how to do this . 236 00:11:05,760 --> 00:11:08,310 We've done second doses before . What 237 00:11:08,310 --> 00:11:10,800 we're just trying to reinforce is that 238 00:11:10,800 --> 00:11:13,650 the second dose availability and timeto 239 00:11:13,650 --> 00:11:16,090 order it for it to be distributed down 240 00:11:16,100 --> 00:11:19,830 on prepare for second shots the week 241 00:11:19,830 --> 00:11:22,920 of for January . Eso were ahead of that 242 00:11:22,920 --> 00:11:25,280 were ahead of the curve on . It's about 243 00:11:25,280 --> 00:11:28,510 communications open , transparent on 244 00:11:28,510 --> 00:11:30,870 collaborative to ensure our success . 245 00:11:31,340 --> 00:11:34,640 So I will close this year . Uh , the 246 00:11:34,640 --> 00:11:37,370 year here this week's , uh , briefing 247 00:11:37,370 --> 00:11:41,220 on behalf of Dr Slowly and I , um we 248 00:11:41,220 --> 00:11:43,387 normally say thanks to all the men and 249 00:11:43,387 --> 00:11:45,660 women serving around the world on their 250 00:11:45,660 --> 00:11:47,680 families in defense of our great 251 00:11:47,680 --> 00:11:50,840 country . But the both of us would just 252 00:11:50,840 --> 00:11:52,990 like to say thank you . Thank you . 253 00:11:52,990 --> 00:11:55,046 Thank you . To the men and women who 254 00:11:55,046 --> 00:11:57,157 are on the front lines . Right in our 255 00:11:57,157 --> 00:11:59,690 hospitals . Emergency rooms . 256 00:11:59,700 --> 00:12:03,550 Uh , excuse me . I see . 257 00:12:03,550 --> 00:12:06,430 Use right . The doctors , the nurses , 258 00:12:06,430 --> 00:12:09,520 the people that support him . 24 7 259 00:12:09,530 --> 00:12:12,880 really truly on the front lines on our 260 00:12:12,880 --> 00:12:14,991 hats are off to everything they dio . 261 00:12:14,991 --> 00:12:17,500 So with that said , um , I just wanna 262 00:12:17,500 --> 00:12:19,720 say Happy New Year's and merry 263 00:12:19,720 --> 00:12:22,660 Christmas to everybody on , uh , on 264 00:12:22,660 --> 00:12:25,590 behalf of Dr Slowly and I So please 265 00:12:25,600 --> 00:12:29,530 questions . Great . Thank you very 266 00:12:29,530 --> 00:12:32,810 much . All right , so that will begin 267 00:12:32,810 --> 00:12:35,032 to question and answer session . If you 268 00:12:35,032 --> 00:12:37,254 do have a question you made , I'll star 269 00:12:37,254 --> 00:12:39,254 one on , mute your phone and record 270 00:12:39,254 --> 00:12:41,421 your name and media outlet . Clearly , 271 00:12:41,421 --> 00:12:43,477 it is required to introduce you . If 272 00:12:43,477 --> 00:12:45,810 you would like to withdraw the question , 273 00:12:45,810 --> 00:12:47,866 you can dial star too . Again , it's 274 00:12:47,866 --> 00:12:50,350 star one in . Our first question here 275 00:12:50,350 --> 00:12:52,470 will come from Danburg Anno with 276 00:12:52,480 --> 00:12:55,580 buzzfeed News in your line is now open . 277 00:12:56,340 --> 00:12:58,396 Thank you , Dan for Ghana . BuzzFeed 278 00:12:58,396 --> 00:13:01,660 news on happy holidays , Guys . Uh , Dr 279 00:13:01,670 --> 00:13:03,837 Plouay invited us to ask him about his 280 00:13:03,837 --> 00:13:05,726 views on on blinding the clinical 281 00:13:05,726 --> 00:13:07,781 trials . That an earlier session , I 282 00:13:07,781 --> 00:13:09,948 was wondering , Does he does he have a 283 00:13:09,948 --> 00:13:12,059 view on whether the modern one should 284 00:13:12,059 --> 00:13:14,170 be on blinded in the way they want or 285 00:13:14,170 --> 00:13:16,059 more like the Pfizer vaccine ? Or 286 00:13:16,059 --> 00:13:18,226 perhaps in the double blinding fashion 287 00:13:18,226 --> 00:13:20,337 that was advocated that the verb pack 288 00:13:20,337 --> 00:13:22,750 meeting thanks very much . Thank you 289 00:13:22,750 --> 00:13:25,610 for the question . Well , my personal 290 00:13:25,610 --> 00:13:28,050 view is , I think it's very important 291 00:13:28,050 --> 00:13:30,830 that we are blind the pilot once and 292 00:13:30,830 --> 00:13:33,530 offer the placebo group to receive 293 00:13:33,530 --> 00:13:36,050 vaccines regardless off their risk . 294 00:13:36,050 --> 00:13:38,840 Kevin , for a number of reasons , I 295 00:13:38,840 --> 00:13:41,007 think the most important is that these 296 00:13:41,007 --> 00:13:43,480 men and women volunteered have bean 297 00:13:43,480 --> 00:13:45,702 instrumental and critical in helping us 298 00:13:45,702 --> 00:13:47,591 develop these vaccines , and they 299 00:13:47,591 --> 00:13:49,758 should be rewarded for it recorded for 300 00:13:49,758 --> 00:13:53,190 it rather than in a way punished for it 301 00:13:53,190 --> 00:13:56,140 by , for instance , being delayed in 302 00:13:56,140 --> 00:13:59,800 receiving the vaccine . Azzan . A 303 00:13:59,810 --> 00:14:02,680 number of time has been proposed and 304 00:14:02,690 --> 00:14:06,470 secondly is the fighter approach , 305 00:14:06,470 --> 00:14:10,270 which I think is intellectually a very 306 00:14:10,270 --> 00:14:12,830 elegant and appropriate one practically 307 00:14:12,830 --> 00:14:15,020 is a very difficult one , because in 308 00:14:15,020 --> 00:14:17,460 real life , every state of our 50 309 00:14:17,460 --> 00:14:19,293 states is gonna make a different 310 00:14:19,293 --> 00:14:21,460 decision in terms of priorities within 311 00:14:21,460 --> 00:14:23,516 the groups who are horrible to , for 312 00:14:23,516 --> 00:14:25,510 instance , on . Therefore , the 313 00:14:25,520 --> 00:14:27,640 companies that end the clinical trial 314 00:14:27,640 --> 00:14:29,740 sites are gonna be scrambling to 315 00:14:29,740 --> 00:14:32,760 appropriately provide the vaccine to 316 00:14:32,760 --> 00:14:36,690 the right sub population within each 317 00:14:36,690 --> 00:14:38,912 state , and then the third reason which 318 00:14:38,912 --> 00:14:41,490 I think is Also very important is that 319 00:14:41,500 --> 00:14:43,870 there are vaccine those that have bean , 320 00:14:44,240 --> 00:14:47,440 uh , to plan for this . Their 321 00:14:47,450 --> 00:14:50,570 stability lifespan is limited 322 00:14:50,650 --> 00:14:53,860 by not immunizing the food population . 323 00:14:53,860 --> 00:14:56,330 At this stage , we haven't lose the 324 00:14:56,330 --> 00:14:58,608 opportunity of using his vaccine doses , 325 00:14:58,608 --> 00:15:00,774 which are different from the vaccine . 326 00:15:00,790 --> 00:15:02,870 This that are being distributed . 327 00:15:03,120 --> 00:15:05,540 Different interests , different batches . 328 00:15:05,540 --> 00:15:07,870 And they they're not counted as part of 329 00:15:07,880 --> 00:15:11,210 the e way those part of the trial 330 00:15:11,210 --> 00:15:13,230 material . And we would lose the 331 00:15:13,230 --> 00:15:15,450 opportunity to immunize quite the size 332 00:15:15,450 --> 00:15:17,394 of a number of individuals without 333 00:15:17,394 --> 00:15:20,260 competing with the rest of the 334 00:15:20,270 --> 00:15:23,170 population on all of this . If we do , 335 00:15:23,170 --> 00:15:26,310 it should incent more people to 336 00:15:26,310 --> 00:15:28,680 participate in the upcoming clinical 337 00:15:28,680 --> 00:15:30,791 trials . Ongoing benefit rise Because 338 00:15:31,140 --> 00:15:33,580 it will remain probably for the next 2 339 00:15:33,580 --> 00:15:35,740 to 3 months but participating in a 340 00:15:35,740 --> 00:15:38,780 clinical trial . It's a faster way toe 341 00:15:38,790 --> 00:15:42,740 access vaccine than thing 342 00:15:42,750 --> 00:15:45,920 than otherwise . That's my my opinion . 343 00:15:45,920 --> 00:15:48,031 Received the FDA and what the company 344 00:15:48,031 --> 00:15:51,290 is ultimately decide . Thank you for 345 00:15:51,290 --> 00:15:53,770 the question . Next question . 346 00:15:55,940 --> 00:15:58,162 Thank you . Our next question here will 347 00:15:58,162 --> 00:16:00,162 come from Tom . How with Washington 348 00:16:00,162 --> 00:16:02,218 time , Tom , your line is now open . 349 00:16:03,140 --> 00:16:05,251 Hey , thanks for doing the call . Can 350 00:16:05,251 --> 00:16:07,418 you give us an update on the long term 351 00:16:07,418 --> 00:16:09,584 care facility partnership with CVS and 352 00:16:09,584 --> 00:16:11,696 Walgreens . How maney sites have they 353 00:16:11,696 --> 00:16:13,584 reached so far ? And what kind of 354 00:16:13,584 --> 00:16:15,584 impact do you expect this effort to 355 00:16:15,584 --> 00:16:17,584 have a mortality rates ? Um , since 356 00:16:17,584 --> 00:16:19,751 nursing homes have been hit so hard by 357 00:16:19,751 --> 00:16:21,950 the pandemic , thank you . So I can 358 00:16:21,950 --> 00:16:23,890 answer the first part . I'm not 359 00:16:23,890 --> 00:16:26,001 qualified to answer the second part . 360 00:16:26,001 --> 00:16:29,370 So we have been in 12 states . Uh , 238 361 00:16:29,370 --> 00:16:33,090 facilities have been , uh , executing 362 00:16:33,090 --> 00:16:36,170 this week on really , uh , 363 00:16:36,180 --> 00:16:39,540 tremendous tremendous effort in 364 00:16:39,550 --> 00:16:42,600 getting everybody done . I mean 365 00:16:42,610 --> 00:16:44,890 Walgreens and CVS or being received by 366 00:16:44,890 --> 00:16:47,200 cheering crowds on their 367 00:16:47,200 --> 00:16:49,200 operationalized in their efforts to 368 00:16:49,200 --> 00:16:51,256 make sure everybody gets the shots , 369 00:16:51,256 --> 00:16:54,000 etcetera . It really , uh , important 370 00:16:54,000 --> 00:16:57,560 to note it is a big effort . As those 371 00:16:57,560 --> 00:17:01,400 70,000 total . I see us multiplying 372 00:17:01,400 --> 00:17:04,200 capability and capacity every day , 373 00:17:04,210 --> 00:17:07,490 Aziz week . As we go on , more vaccine 374 00:17:07,490 --> 00:17:10,420 becomes available for , for example , 375 00:17:10,430 --> 00:17:13,930 we already know that next week that we 376 00:17:13,930 --> 00:17:16,860 are going thio be in close to 13 377 00:17:16,860 --> 00:17:19,630 additional states with another 1000 378 00:17:19,630 --> 00:17:22,230 facilities . Uh , that that will start 379 00:17:22,230 --> 00:17:24,310 to enter . And every week we're just 380 00:17:24,310 --> 00:17:26,900 building on that . Aziz , we go . It's 381 00:17:26,900 --> 00:17:29,030 remember it's based on the governor's 382 00:17:29,030 --> 00:17:32,070 states plans right ? A zehr working 383 00:17:32,070 --> 00:17:34,960 through both front line health care 384 00:17:34,960 --> 00:17:37,900 workers and then the long term health 385 00:17:37,900 --> 00:17:40,360 care facilities . So it's a it's a mix 386 00:17:40,360 --> 00:17:42,790 and strategies on we're enabling their 387 00:17:42,790 --> 00:17:46,670 plants a za 388 00:17:46,670 --> 00:17:48,837 regard . The second question . Part of 389 00:17:48,837 --> 00:17:51,114 the question . You know , the vaccines , 390 00:17:51,114 --> 00:17:53,059 whether the they're not or advisor 391 00:17:53,059 --> 00:17:56,250 vaccine achieved their maximum level of 392 00:17:56,250 --> 00:17:58,860 efficacy within 14 days of the 393 00:17:58,860 --> 00:18:01,230 indication and then with the second 394 00:18:01,230 --> 00:18:04,140 post , probably the immunity is further 395 00:18:04,140 --> 00:18:07,630 reinforce . I am for a long time of its 396 00:18:07,630 --> 00:18:10,100 persistence off course . We did not 397 00:18:10,110 --> 00:18:13,140 have an outcome on prevention of death , 398 00:18:13,150 --> 00:18:15,317 but we did have an out in the trial of 399 00:18:15,317 --> 00:18:18,340 prevention of severe disease , 100% for 400 00:18:18,340 --> 00:18:20,600 both vaccines . And I think it's 401 00:18:20,600 --> 00:18:22,378 reasonable to assume the actual 402 00:18:22,378 --> 00:18:24,322 translated prevention of death and 403 00:18:24,322 --> 00:18:26,830 therefore , within two weeks from 404 00:18:26,830 --> 00:18:29,250 starting to unite subjects that are 405 00:18:29,250 --> 00:18:31,420 living long term care facilities , we 406 00:18:31,420 --> 00:18:33,720 should start to see a decrease in the 407 00:18:33,720 --> 00:18:35,664 overall mortality in the country , 408 00:18:35,664 --> 00:18:37,887 given that the last time I looked about 409 00:18:37,887 --> 00:18:40,530 50% unfortunately off , total death 410 00:18:40,530 --> 00:18:42,680 toll associated with the parliament 411 00:18:42,690 --> 00:18:44,990 came from those populations . The 412 00:18:44,990 --> 00:18:47,140 priority should be to maximize the 413 00:18:47,150 --> 00:18:50,250 number of individuals are immunized in 414 00:18:50,250 --> 00:18:52,270 the long term care facilities if we 415 00:18:52,270 --> 00:18:54,740 want to decrease the death toll 416 00:18:54,750 --> 00:18:57,028 associated with the pandemic . Clearly , 417 00:18:57,028 --> 00:18:59,250 these are decisions that are ultimately 418 00:18:59,250 --> 00:19:02,220 make a state level . There are enough 419 00:19:02,220 --> 00:19:06,150 vaccine to immunize the more than 420 00:19:06,160 --> 00:19:08,750 three million individuals of our living 421 00:19:08,750 --> 00:19:10,694 in such facilities in this state . 422 00:19:11,340 --> 00:19:13,396 Thank you . Next question , please . 423 00:19:16,140 --> 00:19:18,362 Thank you . Our next question here will 424 00:19:18,362 --> 00:19:20,920 come from Rachel Rubin with Politico . 425 00:19:20,930 --> 00:19:22,263 Your line is now open . 426 00:19:26,740 --> 00:19:30,010 I was wondering if you guys could give 427 00:19:30,010 --> 00:19:32,720 an update on the allergic reactions in 428 00:19:32,720 --> 00:19:34,980 the sizer vaccine One if you have a 429 00:19:34,980 --> 00:19:37,960 total of how many reactions have been 430 00:19:37,960 --> 00:19:41,250 and in how many states And also , um , 431 00:19:41,260 --> 00:19:44,920 if there's any more information about 432 00:19:44,920 --> 00:19:48,620 what the reaction is to And , um , also 433 00:19:48,620 --> 00:19:50,731 just real quick on the syringes since 434 00:19:50,731 --> 00:19:52,787 there could be extra doses . Are you 435 00:19:52,787 --> 00:19:54,731 guys sending extra syringes in the 436 00:19:54,731 --> 00:19:58,670 ancillary kids ? Thank you . Thank 437 00:19:58,670 --> 00:20:00,837 you . Maybe I'll take the first part . 438 00:20:00,837 --> 00:20:02,614 And then the accelerant , maybe 439 00:20:02,614 --> 00:20:06,080 Veronica address in terms . So I have 440 00:20:06,080 --> 00:20:08,710 not had an update today . Yesterday 441 00:20:08,710 --> 00:20:11,970 there were six cases on a denominator 442 00:20:11,970 --> 00:20:15,850 that we know is lagging by 2 to 3 days . 443 00:20:16,040 --> 00:20:18,750 Today's mentor is about a million seven 444 00:20:18,750 --> 00:20:20,972 that's in it . I made that . It will be 445 00:20:20,972 --> 00:20:23,200 substantially more than what that 446 00:20:23,200 --> 00:20:26,580 frequency a zit stood yesterday . 447 00:20:26,590 --> 00:20:30,380 Eyes the superior toe . What 448 00:20:30,390 --> 00:20:33,570 one would expect with other vaccines . 449 00:20:33,710 --> 00:20:37,460 I would have expected in the range off , 450 00:20:37,470 --> 00:20:40,890 maybe one person having having , um , 451 00:20:40,890 --> 00:20:42,940 allergic reaction after electoral 452 00:20:42,940 --> 00:20:45,450 reaction and has , of course , with the 453 00:20:45,450 --> 00:20:48,730 fighter vaccine . I'm unaware of any 454 00:20:48,730 --> 00:20:50,960 reports . Associating at this stage 455 00:20:50,970 --> 00:20:52,970 would be more than a vaccine . When 456 00:20:52,970 --> 00:20:55,192 regard off what's happening , there are 457 00:20:55,192 --> 00:20:57,700 discussions with the companies in the N . 458 00:20:57,700 --> 00:21:01,130 I . H to consider running can control 459 00:21:01,140 --> 00:21:04,350 in highly a topic very allergic 460 00:21:04,440 --> 00:21:06,662 subjects . Subjects of , for instance , 461 00:21:06,740 --> 00:21:08,851 have to carry an EpiPen with them all 462 00:21:08,851 --> 00:21:11,420 the time or have a significant not on a 463 00:21:11,420 --> 00:21:14,210 topic productions . To immunize them 464 00:21:14,280 --> 00:21:17,430 with this vaccine , potentially other 465 00:21:17,430 --> 00:21:20,940 vaccine and prepare react the rate of 466 00:21:20,940 --> 00:21:23,990 reactions but also critically be able 467 00:21:23,990 --> 00:21:26,870 to harvest . You know , serum and blood 468 00:21:26,870 --> 00:21:29,550 cells , etcetera to analyze the Indian 469 00:21:29,560 --> 00:21:33,040 status prior and basically after such 470 00:21:33,040 --> 00:21:35,090 reactions . That may happen if they 471 00:21:35,100 --> 00:21:38,390 happen . I think that's really the way 472 00:21:38,400 --> 00:21:40,660 to try to understand exactly the 473 00:21:40,660 --> 00:21:42,890 mechanism . What is it that's provoking 474 00:21:42,890 --> 00:21:45,210 these elections ? Is it true ? 475 00:21:45,220 --> 00:21:48,710 Anaphylactic shock ? I think We're not 476 00:21:48,710 --> 00:21:51,020 clear . That's the case , is it ? I'm 477 00:21:51,020 --> 00:21:53,270 past self congratulation , which is one 478 00:21:53,270 --> 00:21:55,560 of the ways by which we can have this 479 00:21:55,560 --> 00:21:58,000 kind of reaction is associated with the 480 00:21:58,010 --> 00:21:59,899 fact that we have articles that I 481 00:21:59,899 --> 00:22:03,230 injected eyes . It's something eyes it 482 00:22:03,230 --> 00:22:05,550 Is it antibodies to be for the Internet 483 00:22:05,550 --> 00:22:08,400 like all idea , as it's , uh , in which 484 00:22:08,400 --> 00:22:10,580 case things may be different from what 485 00:22:10,590 --> 00:22:12,757 it seemed to the other because they're 486 00:22:12,757 --> 00:22:14,979 leaving different format of the debt is 487 00:22:14,979 --> 00:22:17,034 our important , important scientific 488 00:22:17,034 --> 00:22:19,700 questions that could be addressed in 489 00:22:19,700 --> 00:22:23,030 tow . Descriptive trial . It's being 490 00:22:23,040 --> 00:22:25,262 discussed as a priority because clearly 491 00:22:25,262 --> 00:22:28,030 time important . But at the same time 492 00:22:28,040 --> 00:22:30,900 we'll continue to monitor things . 493 00:22:30,900 --> 00:22:33,780 Reaction now six cases out , off 494 00:22:33,790 --> 00:22:36,260 treatment , pardon or sick or a million 495 00:22:36,270 --> 00:22:39,010 subjects immunized . I think , while 496 00:22:39,020 --> 00:22:41,390 important to understand , still does 497 00:22:41,390 --> 00:22:43,790 not change the safety profile of this 498 00:22:43,790 --> 00:22:45,790 vaccine , particularly now that you 499 00:22:45,790 --> 00:22:47,846 know that those reactions can happen 500 00:22:47,846 --> 00:22:50,620 and therefore organization sites are 501 00:22:50,620 --> 00:22:53,460 equipped with the right medicines and 502 00:22:53,460 --> 00:22:56,990 interventions to help subjects . If on 503 00:22:56,990 --> 00:22:59,160 when they have such reactions , I'll 504 00:22:59,160 --> 00:23:02,220 pass on to the permanent regarding the 505 00:23:02,230 --> 00:23:04,700 ancillary PACs and the assume it's the 506 00:23:04,700 --> 00:23:08,390 six those provided question . So 507 00:23:08,400 --> 00:23:10,930 with respect to the ancillary kits in 508 00:23:10,930 --> 00:23:13,560 support of the vaccine in this , uh , 509 00:23:13,570 --> 00:23:15,870 in your question , the six dose , if 510 00:23:15,870 --> 00:23:18,830 available , we put extra 511 00:23:18,840 --> 00:23:22,310 capability in the kits , right s o that 512 00:23:22,310 --> 00:23:24,254 we would have an over ridge just a 513 00:23:24,254 --> 00:23:26,600 little . Naturally , a swell as 514 00:23:26,600 --> 00:23:29,890 combining most of the administration 515 00:23:29,890 --> 00:23:33,180 going on right now is a major hospitals , 516 00:23:33,180 --> 00:23:36,860 etcetera , where they have access thio 517 00:23:36,870 --> 00:23:39,840 syringes and needles . Accordingly , we 518 00:23:39,840 --> 00:23:43,380 have adjusted our contract and our 519 00:23:43,390 --> 00:23:46,640 construction of the kids to be , um , 520 00:23:46,650 --> 00:23:50,270 to even provide even mawr capability as 521 00:23:50,270 --> 00:23:53,570 we go forward . If they choose Thio . 522 00:23:53,570 --> 00:23:56,020 If six doses still continues to be 523 00:23:56,020 --> 00:23:58,490 available down the road , so feel very 524 00:23:58,490 --> 00:24:01,030 comfortable with the availability of 525 00:24:01,030 --> 00:24:03,620 syringes and needles on our ability to 526 00:24:03,620 --> 00:24:05,676 put these kids together and continue 527 00:24:05,676 --> 00:24:07,840 the simultaneous distribution of the 528 00:24:07,840 --> 00:24:11,370 kits with the vaccine . Thank you . 529 00:24:18,740 --> 00:24:20,962 Thank you . Our next question here will 530 00:24:20,962 --> 00:24:22,740 come from Angelica . Live Edo . 531 00:24:22,740 --> 00:24:24,684 Angelica , your line is now open . 532 00:24:25,340 --> 00:24:27,396 Hello . This is Angelica Libido from 533 00:24:27,396 --> 00:24:29,673 Bloomberg News . Um , question for you , 534 00:24:29,673 --> 00:24:31,896 General Purna , what do you make of the 535 00:24:31,896 --> 00:24:34,118 fact that about one million of the nine 536 00:24:34,118 --> 00:24:36,007 million available doses have been 537 00:24:36,007 --> 00:24:38,250 administered so far ? And are there any 538 00:24:38,250 --> 00:24:40,472 actions the federal government can take 539 00:24:40,472 --> 00:24:42,472 if you feel like the vaccination is 540 00:24:42,472 --> 00:24:46,200 moving too slowly , so I'll start . And 541 00:24:46,200 --> 00:24:48,367 I think maybe Dr Slow we might be able 542 00:24:48,367 --> 00:24:50,478 to help me a little bit . Azzawi Go . 543 00:24:50,478 --> 00:24:52,811 First of all , I think it's a very good , 544 00:24:52,811 --> 00:24:55,490 uh , pace as reserve . We know the 545 00:24:55,490 --> 00:24:58,210 states have a very all of them have a 546 00:24:58,210 --> 00:25:00,432 very good plan . It's , you know , it's 547 00:25:00,432 --> 00:25:03,240 a deliberate plan . Uh , it's about 548 00:25:03,250 --> 00:25:06,200 access to the vaccine when it arrives 549 00:25:06,200 --> 00:25:08,710 and then execution , and we feel very 550 00:25:08,710 --> 00:25:11,630 strongly that they really , really have 551 00:25:11,630 --> 00:25:15,270 set up . And they're immunizing quite a , 552 00:25:15,270 --> 00:25:18,660 uh , quite a bit of people . The as Dr 553 00:25:18,660 --> 00:25:20,716 Slowly mentioned earlier , there's a 554 00:25:20,716 --> 00:25:22,440 lag in the information as it's 555 00:25:22,440 --> 00:25:25,700 collected from all the really thousands 556 00:25:25,700 --> 00:25:28,670 of administration sites on DWI know 557 00:25:28,670 --> 00:25:32,160 that there's probably a least 72 to 96 558 00:25:32,160 --> 00:25:35,870 hour lag in the information uptake . Um , 559 00:25:35,880 --> 00:25:37,960 with that said , we are in 560 00:25:37,960 --> 00:25:40,300 collaboration . We talk every single 561 00:25:40,300 --> 00:25:42,930 day with jurisdictions to make sure 562 00:25:42,930 --> 00:25:45,400 that we're facilitating their plans and 563 00:25:45,400 --> 00:25:48,530 we're best thio add capability and 564 00:25:48,530 --> 00:25:50,930 capacity to help them , uh , either 565 00:25:50,930 --> 00:25:54,900 through maybe pharmacies or extended 566 00:25:54,900 --> 00:25:58,300 use of distribution sites . So I do 567 00:25:58,300 --> 00:26:00,840 believe that will progress here quickly 568 00:26:01,540 --> 00:26:03,596 as as the two things come together . 569 00:26:03,596 --> 00:26:07,280 But Dr Slow anything to add to that I 570 00:26:07,280 --> 00:26:09,502 think you covered . You covered it very 571 00:26:09,502 --> 00:26:11,836 well , you know , for me , I think it's , 572 00:26:11,836 --> 00:26:15,300 uh it's important that the states are 573 00:26:15,310 --> 00:26:18,530 able to increase the cadence 574 00:26:18,530 --> 00:26:21,190 organization , but it's also important 575 00:26:21,190 --> 00:26:23,350 that they move it at the place where 576 00:26:23,350 --> 00:26:25,360 they are in control and that no 577 00:26:25,360 --> 00:26:28,230 mistakes are made or no accidents are 578 00:26:28,230 --> 00:26:30,286 happening . That's super important , 579 00:26:30,286 --> 00:26:33,400 particularly . I just start . And we 580 00:26:33,400 --> 00:26:36,850 are , of course , here to revere their 581 00:26:36,860 --> 00:26:40,610 tasks on bond specific demand . 582 00:26:40,700 --> 00:26:42,550 Now we can have a 583 00:26:44,440 --> 00:26:46,384 thank you . Thank you . Especially 584 00:26:55,840 --> 00:26:57,840 operator . Next question , please . 585 00:26:58,140 --> 00:27:00,460 Thank you very much . Our next question 586 00:27:00,460 --> 00:27:03,040 here will come from Peter Lovefest . 587 00:27:03,050 --> 00:27:06,960 Your line is now open . Peter . Hi . 588 00:27:06,970 --> 00:27:09,192 It's Pete . Losses from The Wall Street 589 00:27:09,192 --> 00:27:11,303 Journal . In the past , you've talked 590 00:27:11,303 --> 00:27:14,480 about , I think , getting to 100 591 00:27:14,490 --> 00:27:16,800 immunizations by the end of February or 592 00:27:16,800 --> 00:27:19,960 by March and that in the second quarter , 593 00:27:20,440 --> 00:27:22,500 I think anyone who get who once one 594 00:27:22,500 --> 00:27:24,222 could get vaccinated . But I'm 595 00:27:24,222 --> 00:27:26,250 wondering how you get there . Is it 596 00:27:26,250 --> 00:27:29,420 with um increasing supplies of these 597 00:27:29,430 --> 00:27:32,000 first two vaccines , or does it depend 598 00:27:32,000 --> 00:27:34,830 upon the introduction of the third or 599 00:27:34,830 --> 00:27:36,350 even fourth vaccine . 600 00:27:39,140 --> 00:27:42,300 Okay , I'll take that . So 601 00:27:42,310 --> 00:27:45,860 the 100 million organizations 602 00:27:46,240 --> 00:27:49,870 can be achieved with the 200 million 603 00:27:49,870 --> 00:27:53,090 doses of vaccine for more than a 604 00:27:53,100 --> 00:27:55,570 fighter that both companies are 605 00:27:55,580 --> 00:27:59,310 committed to deliver between . Now , 606 00:27:59,430 --> 00:28:01,570 at the end of the month of March , 607 00:28:02,040 --> 00:28:04,420 immunization is completed . After to 608 00:28:04,420 --> 00:28:08,080 those on , there are approaches where 609 00:28:08,080 --> 00:28:10,950 we may be able to accelerate through 610 00:28:10,960 --> 00:28:12,960 the delivery off those whose to the 611 00:28:12,960 --> 00:28:16,200 middle of the month of March . The full 612 00:28:16,200 --> 00:28:20,190 immunization may actually depend to 613 00:28:20,190 --> 00:28:22,490 be achieved by by by the moment of 614 00:28:22,490 --> 00:28:24,657 March , depending on whether there are 615 00:28:24,657 --> 00:28:28,150 delays in the delivery off . The last 616 00:28:28,160 --> 00:28:31,040 news from down in our fighter could 617 00:28:31,040 --> 00:28:33,560 depend on the approval off the young 618 00:28:33,560 --> 00:28:36,640 sense vaccine . As I said in my 619 00:28:36,650 --> 00:28:38,650 introduction , That's the one . The 620 00:28:38,660 --> 00:28:42,660 vaccine . We have completed recruitment 621 00:28:42,660 --> 00:28:45,060 in the study . There are cases 622 00:28:45,060 --> 00:28:47,116 approving very significant number of 623 00:28:47,116 --> 00:28:49,130 cases . It's very likely that there 624 00:28:49,130 --> 00:28:52,930 will be , uh , analysis either 625 00:28:52,940 --> 00:28:55,230 criminologists or final , and it's on 626 00:28:55,230 --> 00:28:58,410 efficacy . We are very hopeful , based 627 00:28:58,410 --> 00:29:01,120 on the FX observed after one toe , a 628 00:29:01,130 --> 00:29:03,410 messenger are never seen that high 629 00:29:03,410 --> 00:29:05,410 efficacy will also be achieved with 630 00:29:05,410 --> 00:29:07,632 this vaccine . But of course we need to 631 00:29:07,632 --> 00:29:09,860 wait for wait and see that in assist , 632 00:29:10,640 --> 00:29:14,550 uh , and that that may very well allow 633 00:29:14,550 --> 00:29:17,060 for emergency use authorization firing 634 00:29:17,440 --> 00:29:19,440 the end of the month off January or 635 00:29:19,440 --> 00:29:21,662 early February . And we're working hard 636 00:29:21,662 --> 00:29:24,550 with the company to make sure that 637 00:29:24,550 --> 00:29:26,328 vaccine those that are actually 638 00:29:26,328 --> 00:29:28,780 produced and that will be physically 639 00:29:28,780 --> 00:29:31,640 there and feel , uh , in the amount of 640 00:29:31,640 --> 00:29:35,270 February can actually be released from 641 00:29:35,270 --> 00:29:37,570 a regulatory standpoint because of the 642 00:29:37,570 --> 00:29:40,070 facilities in which they are produced 643 00:29:40,080 --> 00:29:43,140 or Philly finished on . That's what 644 00:29:43,140 --> 00:29:45,260 this ongoing with the FBI as we speak 645 00:29:45,260 --> 00:29:48,250 and J and J . If that was to be 646 00:29:48,250 --> 00:29:49,972 achieved , that can be quite a 647 00:29:49,972 --> 00:29:52,430 significant contribution to the 648 00:29:52,430 --> 00:29:54,486 vaccination of the population in the 649 00:29:54,486 --> 00:29:57,120 month of February and Maurin the Mount 650 00:29:57,120 --> 00:29:59,176 of Black . So I think the likelihood 651 00:29:59,176 --> 00:30:01,009 that 100 million people would be 652 00:30:01,040 --> 00:30:04,940 immunized , but the right first 653 00:30:04,940 --> 00:30:08,710 quarter of 2021 are very 654 00:30:08,710 --> 00:30:12,430 high on then . The 2nd 100 million 655 00:30:12,430 --> 00:30:15,870 options that we now executed with more 656 00:30:15,870 --> 00:30:19,490 than and fighter should allow in 657 00:30:19,490 --> 00:30:21,546 itself to immunize another 100 years 658 00:30:21,546 --> 00:30:24,010 individuals during the second quarter 659 00:30:24,010 --> 00:30:26,850 of the year 2021 . In addition , 660 00:30:26,860 --> 00:30:30,660 uh , Jay and Jay Anson's vaccine can 661 00:30:30,660 --> 00:30:32,660 significantly further increase that 662 00:30:32,660 --> 00:30:34,670 number and you know , we'll see the 663 00:30:34,670 --> 00:30:37,730 Astros and they trying brings . That's 664 00:30:37,740 --> 00:30:41,110 very likely Thio react and allow 665 00:30:41,110 --> 00:30:43,110 foreign Embassy use authorization . 666 00:30:43,350 --> 00:30:46,840 Probably end of February or early March 667 00:30:46,910 --> 00:30:49,530 on , then probably more in April . 668 00:30:49,540 --> 00:30:51,707 We'll have anyway , off novel cracks . 669 00:30:51,707 --> 00:30:55,180 Vaccine , maybe in make a new emergency 670 00:30:55,180 --> 00:30:57,124 reauthorization of the some of his 671 00:30:57,124 --> 00:30:59,291 accent . This is how we think there is 672 00:30:59,291 --> 00:31:02,150 a significant redundancy we start the 673 00:31:02,150 --> 00:31:05,180 second quarter or to achieve the next 674 00:31:05,180 --> 00:31:08,840 200 million vaccines . And as I said 675 00:31:08,840 --> 00:31:11,060 last time , about 80 million of the 676 00:31:11,060 --> 00:31:14,090 population is below the age of 80 18 . 677 00:31:14,090 --> 00:31:17,390 Sorry on the for those 678 00:31:17,390 --> 00:31:20,050 indication at this state on Lee , the 679 00:31:20,050 --> 00:31:23,290 16 to 18 years of age is proved for the 680 00:31:23,300 --> 00:31:26,050 visor . Vaccine trials are ongoing with 681 00:31:26,440 --> 00:31:28,496 Well , they're not Onda , actually . 682 00:31:28,496 --> 00:31:31,510 Also with the youngsters vaccine . And 683 00:31:31,520 --> 00:31:34,590 those may may actually go somewhat 684 00:31:34,590 --> 00:31:37,230 later into the summer because I approve 685 00:31:37,230 --> 00:31:39,960 the maybe , uh , slightly later . 686 00:31:41,140 --> 00:31:44,110 Thank you . Right . Operator , we have 687 00:31:44,110 --> 00:31:47,750 time for two more questions . Great . 688 00:31:47,750 --> 00:31:49,972 Thank you very much . Our next question 689 00:31:49,972 --> 00:31:52,139 here will come from Erika Edwards with 690 00:31:52,139 --> 00:31:54,306 NBC News . Erica , your line is open . 691 00:31:54,440 --> 00:31:56,329 Hi . Thank you so much . If Erika 692 00:31:56,329 --> 00:31:58,384 Edwards with NBC News I'm hoping you 693 00:31:58,384 --> 00:32:00,329 can clarify something . Um , and I 694 00:32:00,329 --> 00:32:02,218 apologize . The doctor style . We 695 00:32:02,218 --> 00:32:04,273 addressed it . His audio is a little 696 00:32:04,273 --> 00:32:03,700 bit garbled . I don't know if there's 697 00:32:03,700 --> 00:32:05,950 any way to fix that , but , um , if I 698 00:32:05,950 --> 00:32:07,950 understood correctly , the original 699 00:32:07,950 --> 00:32:10,190 projection was to vaccinate 20 million 700 00:32:10,190 --> 00:32:12,500 people by the end of this year . Um , 701 00:32:12,500 --> 00:32:14,667 it seems like 20 million vaccines will 702 00:32:14,667 --> 00:32:16,833 be delivered , which is different from 703 00:32:16,833 --> 00:32:19,111 actual shots , and arms is there . Now , 704 00:32:19,111 --> 00:32:20,833 you know , it's changed in the 705 00:32:20,833 --> 00:32:22,833 projection for how many people will 706 00:32:22,833 --> 00:32:25,111 indeed be given that first dose by the , 707 00:32:25,111 --> 00:32:27,333 you know , within the next week or so . 708 00:32:27,333 --> 00:32:30,860 Thank you . That 709 00:32:30,870 --> 00:32:34,650 actually go ahead . So 710 00:32:34,770 --> 00:32:38,360 the the commitment that we can make 711 00:32:38,840 --> 00:32:41,570 is to make , not see those is available 712 00:32:42,140 --> 00:32:45,420 on de every he to give achieved the 713 00:32:45,430 --> 00:32:47,486 first shot of the vaccine because by 714 00:32:47,486 --> 00:32:49,652 definition , second daughter was gonna 715 00:32:49,652 --> 00:32:52,100 hold in the month off January . 716 00:32:52,100 --> 00:32:56,000 Obviously , I think that committing 717 00:32:56,010 --> 00:32:59,280 his met exactly how 718 00:32:59,290 --> 00:33:03,250 fast the ramp up off immunizations 719 00:33:03,250 --> 00:33:06,020 of shorts in arm . What's happening is 720 00:33:06,030 --> 00:33:09,800 is , uh , slower than report . It would 721 00:33:09,800 --> 00:33:13,160 be I said earlier we're here to 722 00:33:13,740 --> 00:33:17,430 to help the states , to 723 00:33:17,430 --> 00:33:19,450 accelerate that appropriately 724 00:33:21,340 --> 00:33:23,396 so that that objective is not met in 725 00:33:23,396 --> 00:33:25,507 terms is unlikely to bring that . But 726 00:33:25,507 --> 00:33:29,410 million people with a shopping arm . Uh , 727 00:33:29,420 --> 00:33:31,420 you know , maybe we'll be surprised 728 00:33:32,640 --> 00:33:35,770 we'll have them allocated before the 729 00:33:35,770 --> 00:33:37,826 end of the month . AST doctor slowly 730 00:33:37,826 --> 00:33:40,170 said , and then they'll the last , uh , 731 00:33:40,180 --> 00:33:41,958 you know , five million will be 732 00:33:41,958 --> 00:33:44,670 delivered the first week in January on 733 00:33:44,670 --> 00:33:46,781 then , you know , uptake from there . 734 00:33:46,781 --> 00:33:50,090 So really , I think a strong message , 735 00:33:50,100 --> 00:33:52,420 uh , in that we're getting the vaccines 736 00:33:52,420 --> 00:33:54,770 out as fast as they are available . 737 00:33:57,640 --> 00:33:58,640 Thank you . 738 00:34:02,040 --> 00:34:04,810 Thank you . And our next question here 739 00:34:04,810 --> 00:34:06,980 will come from can destroy . Candace . 740 00:34:06,980 --> 00:34:10,830 Your line is now open . Hey , Dr Flower , 741 00:34:10,840 --> 00:34:14,200 can you clarify what is being explored 742 00:34:14,200 --> 00:34:16,660 for the moderna dosage ? Is the idea 743 00:34:16,660 --> 00:34:18,660 that people would only be given one 744 00:34:18,660 --> 00:34:21,470 dose ? Possibly . And how quickly will 745 00:34:21,470 --> 00:34:23,526 you know ? How soon will you know if 746 00:34:23,526 --> 00:34:25,526 that's possible ? And is that being 747 00:34:25,526 --> 00:34:28,580 explored for fighter as well ? Well , I 748 00:34:28,580 --> 00:34:30,747 mean , as I expressed a few more other 749 00:34:30,747 --> 00:34:33,410 times , I think one of those vaccine is 750 00:34:33,420 --> 00:34:35,560 totally inappropriate at this stage . 751 00:34:35,940 --> 00:34:37,760 Why ? Because the data we have 752 00:34:37,760 --> 00:34:40,390 generated is with two does is we know 753 00:34:40,390 --> 00:34:42,390 that the second those increases the 754 00:34:42,390 --> 00:34:44,501 strength of the immune response about 755 00:34:44,501 --> 00:34:46,779 10 times in terms of antibody response , 756 00:34:46,779 --> 00:34:50,120 we know that memory installed much , 757 00:34:50,120 --> 00:34:52,860 much stronger and stronger way after a 758 00:34:52,860 --> 00:34:56,210 second those . The system is designed 759 00:34:56,220 --> 00:34:58,442 to the first time experience and Auntie 760 00:34:58,442 --> 00:35:01,420 Jen and then to really 761 00:35:01,430 --> 00:35:05,390 burst when it's it's exactly what we do 762 00:35:05,390 --> 00:35:07,740 Want to give two points is we give 763 00:35:07,740 --> 00:35:09,351 boosters and the year of the 764 00:35:09,351 --> 00:35:11,518 distributors or in five years . That's 765 00:35:11,518 --> 00:35:13,684 how the new system is designed to work 766 00:35:13,684 --> 00:35:17,360 and therefore pursuing a one strategy 767 00:35:17,380 --> 00:35:19,547 with something where the house life is 768 00:35:19,547 --> 00:35:23,440 short is , I think , uh , 769 00:35:23,450 --> 00:35:25,670 something that should be tested 770 00:35:25,670 --> 00:35:27,970 experimentally , not inferred , because 771 00:35:27,970 --> 00:35:30,670 we seek protection for 14 days on seven 772 00:35:30,670 --> 00:35:34,300 days in the Obama or the fighter a 773 00:35:34,300 --> 00:35:36,522 trial . And by the way , that's exactly 774 00:35:36,522 --> 00:35:38,633 the question we're asking the answers 775 00:35:38,633 --> 00:35:40,744 vaccine and in particular , I think I 776 00:35:40,744 --> 00:35:42,578 said that before the young sense 777 00:35:42,578 --> 00:35:44,411 vaccine . It's biology sources , 778 00:35:44,411 --> 00:35:46,633 actually immune response continue to go 779 00:35:46,633 --> 00:35:48,744 even after 90 days after organization 780 00:35:48,744 --> 00:35:51,140 to contrast to almost all protein a 781 00:35:51,140 --> 00:35:53,730 messenger RNA vaccines . Now what we 782 00:35:53,730 --> 00:35:56,790 are exploring is to take advantage off 783 00:35:56,790 --> 00:36:00,580 that second does very significant moves 784 00:36:00,580 --> 00:36:02,880 off the response , decrease the 785 00:36:02,880 --> 00:36:05,600 opposition groups you can achieve again 786 00:36:05,610 --> 00:36:08,590 twice , while the quantity of vaccine 787 00:36:08,590 --> 00:36:11,390 polio vaccine you're giving to those of 788 00:36:11,390 --> 00:36:14,490 50 micrograms , for instance , on the 789 00:36:14,640 --> 00:36:16,751 street drives off the modem . A trial 790 00:36:16,751 --> 00:36:20,440 since the data obtained have suggested 791 00:36:20,440 --> 00:36:22,384 that the 50 microgram does and the 792 00:36:22,384 --> 00:36:23,996 handle microgram . Those are 793 00:36:23,996 --> 00:36:26,218 substantially equivalent , particularly 794 00:36:26,218 --> 00:36:30,130 in people that are not very old under 795 00:36:30,130 --> 00:36:32,408 four that doesn't have needed to speak , 796 00:36:32,408 --> 00:36:34,910 explored on and discuss with the 797 00:36:34,910 --> 00:36:36,840 company . And 798 00:36:41,730 --> 00:36:44,730 on that , I'd like Thio in the network . 799 00:36:44,740 --> 00:36:46,962 Almost a lot of people in the operation 800 00:36:47,330 --> 00:36:50,960 thank a lot of people into the 801 00:36:50,960 --> 00:36:54,460 operation . They have participated the 802 00:36:54,470 --> 00:36:56,359 thousands or tens of thousands of 803 00:36:56,359 --> 00:36:59,200 people , uh , in the manufacturing 804 00:36:59,200 --> 00:37:02,060 sites in the laboratories , various 805 00:37:02,060 --> 00:37:04,290 agencies in the private companies 806 00:37:04,290 --> 00:37:08,210 Madonna Factor , J and J . AstraZeneca , 807 00:37:08,220 --> 00:37:10,450 Mobil , Exxon , Okay , and GSK . But 808 00:37:10,450 --> 00:37:13,550 also all the manufacturing companies 809 00:37:13,930 --> 00:37:17,900 Onda and crisply , now well over 810 00:37:17,900 --> 00:37:20,150 100,000 subjects that have volunteered 811 00:37:20,160 --> 00:37:22,327 into the Clintons For us , it's our on 812 00:37:22,327 --> 00:37:24,327 going into the as Merry Christmas , 813 00:37:24,327 --> 00:37:26,382 Happy New Year to everybody . And we 814 00:37:26,382 --> 00:37:28,160 look forward , Thio significant 815 00:37:28,160 --> 00:37:31,020 progress between now and our next next 816 00:37:31,030 --> 00:37:33,252 opportunity to be Thank you very much . 817 00:37:34,730 --> 00:37:36,786 Ladies and gentlemen , thank you for 818 00:37:36,786 --> 00:37:38,952 joining the call today . Please direct 819 00:37:38,952 --> 00:37:41,008 any unanswered questions to media at 820 00:37:41,008 --> 00:37:43,230 HHS dot gov and have a happy holidays . 821 00:37:43,230 --> 00:37:43,670 Thank you very much .